Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 49; no. 42; pp. 4797 - 4799
Main Authors Peck, Kristy L, Clewett, Heather S, Schmitt, Jennifer C, Shearer, Jason
Format Journal Article
LanguageEnglish
Published England 25.05.2013
Subjects
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - genetics
Coordination Complexes - chemistry
Copper - chemistry
Molecular Dynamics Simulation
Mutation
Oxidation-Reduction
Oxygen - chemistry
Peptide Fragments - chemistry
Peptide Fragments - genetics
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Summary:Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc40326b