Cover Picture: Specific Design of Titanium(IV) Phenolato Chelates Yields Stable and Accessible, Effective and Selective Anticancer Agents (Chem. Eur. J. 29/2016)

• Published in: Chemistry : a European journal Vol. 22; no. 29; p. 9845
• Main Authors: Meker, Sigalit, Braitbard, Ori, Hall, Matthew D., Hochman, Jacob, Tshuva, Edit Y.
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 11.07.2016; Wiley Subscription Services, Inc
• Subjects: Accessibility; Animal models; Anticancer properties; Antitumor agents; Apoptosis; Biocompatibility; Biotechnology; Cancer; Chelates; Chemistry; drug design; Formulations; In vitro methods and tests; ligand design; N,O ligands; O ligands; Surgical implants; Titanium; Toxicity
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201602398

Titanium phenolato anticancer complex of a single hexadentate tetraanionic ligand aced it all! It is stable for weeks in biological environments, with negligible loss of activity after preincubation for days in medium and serum; it is widely effective in vitro towards 56 cell lines and in vivo in murine models; it is biologically accessible, demonstrating its activity in vitro and in vivo without formulations; it is markedly selective to cancer cells, with no clinical signs of toxicity to treated animals, and indications of apoptotic pathways involved. More information can be found in the Full Paper by E. Y. Tshuva et al. on page 9986 ff.