The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells

Neuroinflammation and neurogenesis have both been the subject of intensive investigation over the past 20 years. The sheer complexity of their regulation and their ubiquity in various states of health and disease have sometimes obscured the progress that has been made in unraveling their mechanisms...

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Published inHealth psychology & behavioral medicine Vol. 3; no. 2; p. NS20180208
Main Authors Lucassen, Paul J., van Dam, Anne-Marie, Kandel, Prasanna, Bielefeld, Pascal, Korosi, Aniko, Fitzsimons, Carlos P., Maletic-Savatic, Mirjana
Format Journal Article
LanguageEnglish
Published England Portland Press Ltd 01.06.2019
Subjects
Commentaries
Developmental Biology
Immunology & Inflammation
Molecular Interactions
Neuroscience
neurogenesis
TLX
hippocampus
microglia
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Summary:Neuroinflammation and neurogenesis have both been the subject of intensive investigation over the past 20 years. The sheer complexity of their regulation and their ubiquity in various states of health and disease have sometimes obscured the progress that has been made in unraveling their mechanisms and regulation. A recent study by Kozareva et al. (Neuronal Signaling (2019) 3), provides evidence that the orphan nuclear receptor TLX is central to communication between microglia and neural precursor cells and could help us understand how inflammation, mediated by microglia, influences the development of new neurons in the adult hippocampus. Here, we put recent studies on TLX into the context of what is known about adult neurogenesis and microglial activation in the brain, along with the many hints that these processes must be inter-related.
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ISSN:2059-6553
2059-6553
2164-2850
DOI:10.1042/NS20180208