Blood lipid profiles associated with metastatic sites in advanced gastric cancer

• Published in: BMC gastroenterology Vol. 24; no. 1; pp. 1 - 7
• Main Authors: Zhang, Hui, Liu, Yiming, Feng, Li, Wang, Long, Han, Jing, Zhang, Xue, Wang, Yudong, Li, Dan, Liu, Jiayin, Liu, Yan, Jin, Hui, Fan, Zhisong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 04.11.2024; BioMed Central; BMC
• Subjects: Adenocarcinoma; Age; Analysis and chemistry; Apolipoprotein B; Apolipoproteins; Biopsy; Blood; Blood levels; Body mass index; Care and treatment; Cholesterol; Development and progression; Diagnosis; Females; Gastric adenocarcinoma; Gastric cancer; Health aspects; High density lipoprotein; Lipids; Lipoprotein A; Lipoproteins; Lipoproteins (very low density); Liver cancer; Low density lipoprotein; Low density lipoproteins; Lung cancer; Lymph nodes; Lymphocytes; Medical research; Medicine, Experimental; Metastases; Metastasis; Metastatic sites; Multivariate analysis; Normal distribution; Ovarian cancer; Ovaries; Peripheral blood; Peritoneal metastasis; Peritoneum; Prostate; Regression analysis; Risk factors; Signal transduction; Stomach cancer; Total cholesterol; Triglycerides; Tumors; Very low-density lipoprotein cholesterol; Women; China
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-024-03479-2

Background This study explored the correlation between peripheral blood lipid levels and clinicopathological parameters in patients with advanced gastric cancer (GC), focusing on changes in lipid levels during disease progression. Methods Pathological features and serum lipid profiles of 179 patients with stage III-IV gastric adenocarcinoma were analyzed. Lipid parameters examined included total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), apolipoprotein AI (Apo AI), apolipoprotein B (Apo B), lipoprotein(a) (Lp(a)), among others. The total cholesterol-lymphocyte score (TL score) and BMI were also calculated. The association between lipid parameters and clinicopathological characteristics such as age, gender, family history, and metastasis sites was assessed. Results In GC patients, females had higher TG levels than males. Patients with peritoneal metastasis had significantly lower levels of TC, LDL-C, Apo B, and B/A ratio. Those with lung metastasis exhibited higher LDL-C levels and lower levels of VLDL-C. No significant associations were found between lipid levels and metastasis to distant lymph nodes, liver, or bone. Female patients with ovarian metastasis had significantly lower VLDL-C levels. Multivariate analysis revealed low TC as an independent risk factor for peritoneal metastasis, high LDL-C and low VLDL-C levels for lung metastasis, and younger age and low VLDL-C for ovarian metastasis. Conclusion Specific blood lipid levels are significantly associated with metastatic sites in advanced gastric cancer. Lipid profiles could serve as potential biomarkers for predicting metastatic sites in GC patients. Keywords: Gastric adenocarcinoma, Lipids, Total cholesterol, Very low-density lipoprotein cholesterol, Metastatic sites, Peritoneal metastasis, Lung metastasis