Comparison between clot waveform analysis (CWA) of normal and abnormal aPTT of sepsis patients in Dr. Hasan Sadikin Hospital Bandung

• Published in: Journal of physics. Conference series Vol. 1246; no. 1; pp. 12044 - 12049
• Main Authors: Rahmawati, Eny, Zamalek Dalimoenthe, Nadjwa, Prihatni, Delita
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.07.2019
• Subjects: Blood vessels; Coagulation; Hemostatics; Immune system; Sepsis; Toxins; Waveform analysis; Waveforms
• ISSN: 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/1246/1/012044

Sepsis is a clinical syndrome caused by the entry of harmful pathogens toxins into the blood vessels, which will cause the immune system response and ultimately will also interfere with hemostasis system including coagulation system which can end up with DIC. Therefore, monitoring of coagulation in sepsis becomes very important. The examination of coagulation such as PT and aPTT by mechanical methods only provide information about the timing of the coagulation and completely unknown how the coagulation process occurs. The Currently available coagulometer tool that checks the coagulation system with photo optical method to visualize the waveforms clot (Clot Waveform Analysis). This study was to determine the difference between CWA of normal and abnormal aPTT in sepsis patients. It was conducted at the Laboratory of Clinical Pathology, RSUP Dr. Hasan Sadikin Bandung. The subjects were all patients diagnosed with sepsis based on SOFA sepsis criteria, in the period of May 1, 2016, until August 31, 2016, were examined aPTT by CS2100i. The CWA were obtained from the examination of aPTT with the tool. Waveform of aPTT in sepsis was a biphasic waveform if the value of slope_ 1> -0.25% T / sec. The waveform were found in normal aPTT (83.33%) and prolonged aPTT group (100%). It were occured in the most normal aPTT groups and in all subjects with prolonged aPTT.This finding was useful for the treatment of sepsis patients when aPTT is normal because it proved that in sepsis patients with normal aPTT shows a biphasic waveform.