A nine‐coordinated bismuth(III) Schiff‐base complex: Design, synthesis, computational studies, and antimicrobial activity

• Published in: Applied organometallic chemistry Vol. 36; no. 2
• Main Authors: Lei, Yan‐Hua, Jiang, Jian‐Hong, Li, Xu, Li, Qiang‐Guo, Li, Chuan‐Hua
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.02.2022
• Subjects: Antiinfectives and antibacterials; Antimicrobial agents; Band theory; bio‐microcalorimetry; Bismuth; bismuth(III) complex; Chemistry; Crystal structure; DFT calculations; Imines; Infrared spectra; Mannitol; Mathematical analysis; Raman spectra; Schiff base; Single crystals; thermokinetic parameters; Yeast
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.6523

A new bismuth(III) Schiff‐base complex [Bi2(HL)2(NO3)4] was synthesized by using equivalent molar of Schiff‐base ligand [H2L = (E)‐N′‐(2‐hydroxy‐3‐methoxybenzylidene)isonicotinohydrazide] and Bi(NO3)3•5H2O with the assistance of Mannitol. The complex was structurally characterized by elemental analysis, spectroscopic methods, and single crystal X‐ray diffraction. The experimental and theoretical vibrational bands (infrared and Raman spectra) have been discussed. The antimicrobial activity of the complex against Schizosaccharomyces pombe was evaluated by bio‐microcalorimetry at 32°C. Some thermokinetic parameters (k, Pmax, tG, and Qtotal) were obtained from the metabolic power–time curves of S. pombe, and their quantitative relationships with the concentration (c) were discussed. The half inhibition concentrations (IC50) of isoniazid, Schiff base, and the complex were calculated. The complex showed the strongest inhibition effect among three compounds. A new bismuth(III) Schiff‐base complex [Bi2(HL)2(NO3)4] was synthesized and structurally characterized by single crystal X‐ray diffraction. DFT calculations of the complex were performed and confirmed the experimental data. The antimicrobial activity of the complex against S. pombe was evaluated by bio‐microcalorimetry. Some quantitative metabolic parameters (k, I, Pmax, tG, and Qtotal) were derived. The complex had much stronger antimicrobial activity than isoniazid and Schiff base.