Surface modification of poly(2‐hydroxyethyl methacrylate) hydrogel for contact lens application

The present study examined poly(2‐hydroxyethyl methacrylate) (PHEMA)‐based hydrogels that have been extensively used in biomedical applications, including contact lens. In this research, we aimed to reduce adsorption of protein components from tears and bacterial deposition by surface modification o...

Full description

Saved in:
Bibliographic Details
Published inPolymers for advanced technologies Vol. 29; no. 4; pp. 1227 - 1233
Main Authors Kazemi Ashtiani, Mohammad, Zandi, Mojgan, Shokrollahi, Parvin, Ehsani, Morteza, Baharvand, Hossein
Format Journal Article
LanguageEnglish
Published Bognor Regis Wiley Subscription Services, Inc 01.04.2018
Subjects
antifouling biomaterial
Atomic force microscopy
Biomedical materials
Chemical properties
contact lens
Contact lenses
Deposition
Functional groups
Hydrogels
Polyhydroxyethyl methacrylate
protein absorption
Protein adsorption
Proteins
Sulfuric acid
Surface chemistry
surface modification
Tearing
Online AccessGet full text

Cover

More Information
Summary:The present study examined poly(2‐hydroxyethyl methacrylate) (PHEMA)‐based hydrogels that have been extensively used in biomedical applications, including contact lens. In this research, we aimed to reduce adsorption of protein components from tears and bacterial deposition by surface modification of the hydrogel with different functional groups that included carboxylic acid, primary amine, and quaternary ammonium. The PHEMA was treated with a solution of sulfuric acid for partial hydrolysis of the HEMA ester groups to induce acid groups on the surface of the hydrogel. Carboxylic acid groups of the modified PHEMA were converted to primary amine and quaternary ammonium groups via carbodiimide chemistry. The surface physical and chemical properties of different samples were investigated by atomic force microscopy and X‐ray photoelectron spectroscopy, respectively. We conducted the bicinchoninic acid assay to evaluate protein deposition from artificial tear fluid on samples. Antibacterial properties of the modified hydrogels were investigated with a culture of Staphylococcus aureus, one of the major causes of eye infections. Our data showed that positively charged amine and ammonium groups efficiently resisted protein adsorption and bacterial deposition compared to alcohol and carboxylic acid groups.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.4233