Polycaprolactone and its derivatives for drug delivery

Polycaprolactone (PCL) is polymer of 21st centuries. PCL is a biodegradable and biocompatible polymer used for various healthcare applications. This review explores the properties, synthesis, and processing of PCL. The use of PCL polymer for nanoparticles (NPs), microparticles, films, and fibers off...

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Published inPolymers for advanced technologies Vol. 34; no. 10; pp. 3296 - 3316
Main Authors Pawar, Ranjitsinh, Pathan, Anam, Nagaraj, Srishti, Kapare, Harshad, Giram, Prabhanjan, Wavhale, Ravindra
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.10.2023
Wiley Subscription Services, Inc
Subjects
Biocompatibility
biocompatible polymer
biodegradable polymer
Biomedical materials
Health care
healthcare applications
Microparticles
Nanoparticles
PCL‐based materials
Polycaprolactone
Polymers
Surgical implants
Tissue engineering
Wound healing
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Summary:Polycaprolactone (PCL) is polymer of 21st centuries. PCL is a biodegradable and biocompatible polymer used for various healthcare applications. This review explores the properties, synthesis, and processing of PCL. The use of PCL polymer for nanoparticles (NPs), microparticles, films, and fibers offers several advantages for biomedical applications. The review highlights the potential of PCL‐based materials for tissue engineering, drug delivery, wound healing, and implantable medical devices. We also critically analyzed challenges in PCL‐based materials and the strategies used to overcome for successful translation into clinical applications. Overall, this review provides a comprehensive overview of PCL as a valuable biomaterial for healthcare applications.
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ISSN:1042-7147
1099-1581
DOI:10.1002/pat.6140