Uterine serous papillary carcinoma arising inside an endometrial polyp removed by hysteroscopy
Objective To describe a papillary, serous carcinoma arising in an endometrial polyp. Setting Endoscopy unit of a private, urban hospital. Interventions The polyp was diagnosed by hysteroscopy. Polypectomy was carried out using the 27F resectoscope. Steroid receptors and over‐expression for p53 an...
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Published in | Gynaecological endoscopy Vol. 9; no. 5; pp. 331 - 335 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.10.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
To describe a papillary, serous carcinoma arising in an endometrial polyp.
Setting
Endoscopy unit of a private, urban hospital.
Interventions
The polyp was diagnosed by hysteroscopy. Polypectomy was carried out using the 27F resectoscope. Steroid receptors and over‐expression for p53 and c‐erb B2 protein were investigated in the polyp by immunohistochemical methods.
Results
There was a focal area of papillary serous carcinoma in the endometrial polyp. The malignant neoplasm showed over‐expression for p53 and c‐erb B2 oncoprotein and absence of oestrogen and progesterone receptors.
Conclusions
Alteration in the p53 tumour suppressor gene was an early event in the process of carcinogenesis in the polyp of this patient. This was associated with loss of steroid receptors and c‐erb B2 amplification. |
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Bibliography: | ArticleID:GEN330 istex:318886B53FF6B91DED6068BB96CA3CAC78ED5AC7 ark:/67375/WNG-3CGM85F0-4 |
ISSN: | 0962-1091 1365-2508 |
DOI: | 10.1046/j.1365-2508.2000.00330.x |