Effects of potentiated antibodies to brain specific protein S100 on the dynamics of long-term potentiation in hippocampal slices

Native monoclonal antibodies to neurospecific S100 protein completely prevented the development of long-term potentiation (LTP) in rat hippocampal slices. Potentiated antiserum prepared by multiple dilutions according to homeopathic procedure (1:10^sup 12^) did not affect LTP, but abolished the effe...

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Published inBulletin of experimental biology and medicine Vol. 127; no. 3; pp. 286 - 289
Main Authors Epshtein, O. I., Beregovoi, N. A., Sorokina, N. S., Starostina, M. V., Shtark, M. B.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.03.1999
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Summary:Native monoclonal antibodies to neurospecific S100 protein completely prevented the development of long-term potentiation (LTP) in rat hippocampal slices. Potentiated antiserum prepared by multiple dilutions according to homeopathic procedure (1:10^sup 12^) did not affect LTP, but abolished the effect of native antiserum when applied 20 min prior to it. Neither nonimmune rabbit serum at the same dilution nor homeopathic solvent modified the development of LTP in hippocampal slices.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433359