GLP-2: A POORLY UNDERSTOOD MEDIATOR ENROLLED IN VARIOUS BARIATRIC/METABOLIC SURGERY-RELATED PATHOPHYSIOLOGIC MECHANISMS

• Published in: Arquivos brasileiros de cirurgia digestiva : ABCD Vol. 29; no. 4; pp. 272 - 275
• Main Authors: Cazzo, Everton, Gestic, Martinho Antonio, Utrini, Murillo Pimentel, Chaim, Felipe David Mendonça, Geloneze, Bruno, Pareja, José Carlos, Chaim, Elinton Adami, Magro, Daniéla Oliveira
• Format: Journal Article
• Language: English
• Published: Brazil Colégio Brasileiro de Cirurgia Digestiva 01.12.2016
• Subjects: Bariatric Surgery; Biliopancreatic diversion; Gastric Bypass; Glucagon-like peptide 2; Glucagon-Like Peptide 2 - physiology; Humans; Obesity; Postoperative Complications - physiopathology
• ISSN: 0102-6720; 2317-6326; 0102-6720
• DOI: 10.1590/0102-6720201600040014

Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone whose effects are predominantly trophic on the intestinal mucosa. Critically evaluate the current literature on the influence of bariatric/metabolic surgery on the levels of GLP-2 and its potential clinical implications. Narrative review through online research on the databases Medline and Lilacs. There were six prospective human studies, two cross-sectional human studies, and three experimental animal studies selected. There is evidence demonstrating significant increase in the levels of GLP-2 following gastric bypass, Scopinaro operation, and sleeve gastrectomy. There are no differences between gastric bypass and sleeve gastrectomy in regards to the increase in the GLP-2 levels. There is no correlation between the postoperative levels of GLP-2 and the occurrence of adequate or insufficient postoperative weight loss. GLP-2 plays significant roles on the regulation of nutrient absorption, permeability of gut mucosa, control of bone resorption, and regulation of satiety. The overall impact of these effects potentially exerts a significant adaptive or compensatory effect within the context of varied bariatric surgical techniques.