Sertraline-Induced Hypoglycemia in Drug-Induced Liver Injury
Sertraline, a selective serotonin reuptake inhibitor, is a medication recommended as a third line treatment of cholestatic liver injury pruritis. We report a case of a young male who developed liver injury secondary to self-administration of anabolic steroids and who complained of persistent pruriti...
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| Published in | Hospital pharmacy (Philadelphia) Vol. 59; no. 5; pp. 529 - 531 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Los Angeles, CA
SAGE Publications
01.10.2024
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| Abstract | Sertraline, a selective serotonin reuptake inhibitor, is a medication recommended as a third line treatment of cholestatic liver injury pruritis. We report a case of a young male who developed liver injury secondary to self-administration of anabolic steroids and who complained of persistent pruritis leading to a treatment by sertraline. Two days later, the patient was admitted to the hospital with a severe hypoglycemia, while the liver function tests were in amelioration. Clinical and biological evaluation were in favor of sertraline-induced hypoglycemia, a side effect rarely reported in non-diabetic patients, and in the context of hepatic injury. |
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| AbstractList | Sertraline, a selective serotonin reuptake inhibitor, is a medication recommended as a third line treatment of cholestatic liver injury pruritis. We report a case of a young male who developed liver injury secondary to self-administration of anabolic steroids and who complained of persistent pruritis leading to a treatment by sertraline. Two days later, the patient was admitted to the hospital with a severe hypoglycemia, while the liver function tests were in amelioration. Clinical and biological evaluation were in favor of sertraline-induced hypoglycemia, a side effect rarely reported in non-diabetic patients, and in the context of hepatic injury. Sertraline, a selective serotonin reuptake inhibitor, is a medication recommended as a third line treatment of cholestatic liver injury pruritis. We report a case of a young male who developed liver injury secondary to self-administration of anabolic steroids and who complained of persistent pruritis leading to a treatment by sertraline. Two days later, the patient was admitted to the hospital with a severe hypoglycemia, while the liver function tests were in amelioration. Clinical and biological evaluation were in favor of sertraline-induced hypoglycemia, a side effect rarely reported in non-diabetic patients, and in the context of hepatic injury.Sertraline, a selective serotonin reuptake inhibitor, is a medication recommended as a third line treatment of cholestatic liver injury pruritis. We report a case of a young male who developed liver injury secondary to self-administration of anabolic steroids and who complained of persistent pruritis leading to a treatment by sertraline. Two days later, the patient was admitted to the hospital with a severe hypoglycemia, while the liver function tests were in amelioration. Clinical and biological evaluation were in favor of sertraline-induced hypoglycemia, a side effect rarely reported in non-diabetic patients, and in the context of hepatic injury. |
| Author | Khanfour, Melissa Mikhael, Elio El Helou, Santa Yaghi, César Amer, Lamis Slim, Rita |
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| Cites_doi | 10.4158/EP15616.CR 10.1152/ajpendo.00772.2007 10.2165/00003088-200241150-00002 10.1002/hep.21553 10.1016/j.jhep.2009.04.009 10.1016/j.jsbmb.2008.12.022 10.1038/clpt.1981.154 10.1097/FPC.0000000000000392 10.1210/js.2019-SUN-184 10.1152/ajpendo.00405.2004 |
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| Keywords | drug-induced liver injury medication safety selective serotonin reuptake inhibitors hypoglycemia |
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| References | DeVane, Liston, Markowitz 2002; 41 Huddart, Hicks, Ramsey 2020; 30 2009; 51 Saad, Gooren 2009; 114 Mayo, Handem, Saldana, Jacobe, Getachew, Rush 2007; 45 Sanders, Wilkinson, Taborsky 2008; 294 Ni, Khosla, Nylen 2016; 2 Moore, DiCostanzo, Dardevet, Lautz, Farmer, Cherrington 2005; 288 Bhargava, Ruby, Fleming 2019; 3 Naranjo, Busto, Sellers 1981; 30 bibr3-00185787241242767 bibr8-00185787241242767 bibr5-00185787241242767 bibr1-00185787241242767 bibr4-00185787241242767 bibr9-00185787241242767 bibr2-00185787241242767 bibr7-00185787241242767 bibr10-00185787241242767 bibr6-00185787241242767 |
| References_xml | – volume: 294 issue: 5 year: 2008 article-title: The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia publication-title: Am J Physiol Endocrinol Metab contributor: fullname: Taborsky – volume: 51 start-page: 237 issue: 2 year: 2009 end-page: 267 article-title: EASL Clinical Practice Guidelines: management of cholestatic liver diseases publication-title: J Hepatol – volume: 288 issue: 3 year: 2005 article-title: Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs publication-title: Am J Physiol Endocrinol Metab contributor: fullname: Cherrington – volume: 41 start-page: 1247 issue: 15 year: 2002 end-page: 1266 article-title: Clinical pharmacokinetics of sertraline: publication-title: Clin Pharmacokinet contributor: fullname: Markowitz – volume: 30 start-page: 239 issue: 2 year: 1981 end-page: 245 article-title: A method for estimating the probability of adverse drug reactions publication-title: Clin Pharmacol Ther contributor: fullname: Sellers – volume: 45 start-page: 666 issue: 3 year: 2007 end-page: 674 article-title: Sertraline as a first-line treatment for cholestatic pruritus publication-title: Hepatology contributor: fullname: Rush – volume: 2 issue: 1 year: 2016 article-title: Sertraline-induced hypoglycemia in type 2 diabetes patients publication-title: AACE Clin Case Rep contributor: fullname: Nylen – volume: 114 start-page: 40 issue: 1-2 year: 2009 end-page: 43 article-title: The role of testosterone in the metabolic syndrome: a review publication-title: J Steroid Biochem Mol Biol contributor: fullname: Gooren – volume: 3 year: 2019 article-title: SUN-184 sertraline-induced hypoglycemia in nondiabetic patients publication-title: J Endocr Soc contributor: fullname: Fleming – volume: 30 start-page: 26 issue: 2 year: 2020 end-page: 33 article-title: PharmGKB summary: sertraline pathway, pharmacokinetics publication-title: Pharmacogenet Genomics contributor: fullname: Ramsey – ident: bibr3-00185787241242767 doi: 10.4158/EP15616.CR – ident: bibr5-00185787241242767 doi: 10.1152/ajpendo.00772.2007 – ident: bibr7-00185787241242767 doi: 10.2165/00003088-200241150-00002 – ident: bibr8-00185787241242767 doi: 10.1002/hep.21553 – ident: bibr1-00185787241242767 doi: 10.1016/j.jhep.2009.04.009 – ident: bibr2-00185787241242767 doi: 10.1016/j.jsbmb.2008.12.022 – ident: bibr9-00185787241242767 doi: 10.1038/clpt.1981.154 – ident: bibr10-00185787241242767 doi: 10.1097/FPC.0000000000000392 – ident: bibr4-00185787241242767 doi: 10.1210/js.2019-SUN-184 – ident: bibr6-00185787241242767 doi: 10.1152/ajpendo.00405.2004 |
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| Title | Sertraline-Induced Hypoglycemia in Drug-Induced Liver Injury |
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