Fatal septicemia in 2 South American camelids with caudal C3-pyloric-duodenal adenocarcinoma

• Published in: Journal of veterinary diagnostic investigation Vol. 36; no. 3; p. 473
• Main Authors: Abad, Clemer, Fritz, Heather, Gonzales-Viera, Omar
• Format: Journal Article
• Language: English
• Published: United States 01.05.2024
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - veterinary; Animals; Camelids, New World; Duodenal Neoplasms - pathology; Duodenal Neoplasms - veterinary; Escherichia coli - isolation & purification; Escherichia coli Infections - microbiology; Escherichia coli Infections - pathology; Escherichia coli Infections - veterinary; Fatal Outcome; Sepsis - microbiology; Sepsis - veterinary; Streptococcal Infections - microbiology; Streptococcal Infections - pathology; Streptococcal Infections - veterinary; camelids; adenocarcinoma; stomach; llamas; alpacas; duodenum
• ISSN: 1943-4936
• DOI: 10.1177/10406387241239920

Gastrointestinal adenocarcinomas are often reported in South American camelids (SAC). We describe here cases of gastroduodenal adenocarcinoma in an adult alpaca ( ) and a llama ( ); both SACs were anorectic and lethargic before death. At autopsy, a prominent and firm caudal C3-pyloric-duodenal junction with stricture and ulceration was present in both animals, as were hemorrhages in various organs and hydrothorax. Microscopically, scattered nests, cords, and tortuous acini of neoplastic epithelial cells were embedded in desmoplastic stroma and invaded the submucosa and muscle layers of the gastroduodenal junction. The mucosa was necrotic, with gram-negative rods in the alpaca and colonies of gram-positive cocci in the llama. No tumor metastases were observed. The neoplastic cells immunolabeled for pancytokeratin. was isolated from the alpaca and from the llama; septicemia was the cause of death in both animals. Although adenocarcinomas arising from gastric compartments and intestinal segments have been reported in SACs, adenocarcinoma of the caudal C3-pyloric-duodenal junction has not been reported previously in these species, to our knowledge.