Pancreatic pseudocyst in the setting of chronic pancreatitis and pancreas divisum

The leading theory regarding the pathophysiology of the association between pancreas divisum and recurrent acute pancreatitis or chronic pancreatitis is the presence of a stenotic minor papilla predisposing certain patients to outflow obstruction; this obstruction is the actual risk factor that resu...

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Bibliographic Details
Published inThe American surgeon Vol. 74; no. 8; pp. 775 - 777
Main Authors Mukherjee, Kaushik, Melvin, Willie V
Format Journal Article
LanguageEnglish
Published United States SAGE PUBLICATIONS, INC 01.08.2008
Subjects
Adult
Cholangiopancreatography, Magnetic Resonance
Cysts
Diagnosis, Differential
Endoscopy
Female
Humans
Pancreas
Pancreatic Ducts - abnormalities
Pancreatic Pseudocyst - diagnosis
Pancreatic Pseudocyst - etiology
Pancreatic Pseudocyst - surgery
Pancreatitis, Chronic - complications
Pancreatitis, Chronic - therapy
Patients
Recurrence
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Summary:The leading theory regarding the pathophysiology of the association between pancreas divisum and recurrent acute pancreatitis or chronic pancreatitis is the presence of a stenotic minor papilla predisposing certain patients to outflow obstruction; this obstruction is the actual risk factor that results in a tendency for certain patients to have recurrent pancreatitis, whereas others remain asymptomatic. Response of the cystic fibrosis transmembrane regulator protein in the nasal epithelium of patients with pancreas divisum and recurrent acute pancreatitis is decreased (13 mV) compared with normal controls (22 mV), but not as low as in patients with cystic fibrosis (-1 mV in patients with sufficient pancreatic exocrine function and -3 mV in patients with pancreatic insufficiency).
ISSN:0003-1348
1555-9823
DOI:10.1177/000313480807400822