Intracellular Zn(ii) induced turn-on fluorescence of an l-phenylalanine-derived pseudopeptide

A C-2 symmetric l-phenylalanine-derived pseudopeptide has been synthesized for selective and sensitive recognition of Zn(ii) ions in aqueous-organic media. The pseudopeptidic probes exhibit intracellular Zn(ii) ion-sensing capabilities as demonstrated via live-cell fluorescence studies on RAW264.7 c...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 44; pp. 8823 - 8828
Main Authors Tamrakar, Arpna, Kumar, Praveen, Garg, Neha, Luis, Santiago V., Pandey, Mrituanjay D.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 15.11.2023
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Organic
Fluorescence
Intracellular
Phenylalanine
Physical Sciences
Science & Technology
Zinc
CU2
CHEMOSENSOR
RECOGNITION
DISCRIMINATION
COMPLEXES
SENSOR
COORDINATION
METAL-IONS
ZINC
ZN2
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Summary:A C-2 symmetric l-phenylalanine-derived pseudopeptide has been synthesized for selective and sensitive recognition of Zn(ii) ions in aqueous-organic media. The pseudopeptidic probes exhibit intracellular Zn(ii) ion-sensing capabilities as demonstrated via live-cell fluorescence studies on RAW264.7 cells. Hence, we present a bioinspired pseudopeptide for potential biological applications involving intracellular Zn(ii) ion detection.
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SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01337e