Oral sucralfate in acute radiation oesophagitis

• Published in: Acta oncologica Vol. 33; no. 1; p. 61
• Main Authors: Sur, R K, Kochhar, R, Singh, D P
• Format: Journal Article
• Language: English
• Published: England 1994
• Subjects: Administration, Oral; Alginates - therapeutic use; Brachytherapy - adverse effects; Esophagitis - drug therapy; Esophagitis - etiology; Glucuronic Acid; Hexuronic Acids; Humans; Prospective Studies; Radiation-Protective Agents - therapeutic use; Radiotherapy - adverse effects; Sucralfate - administration & dosage; Sucralfate - therapeutic use
• ISSN: 0284-186X; 1651-226X
• DOI: 10.3109/02841869409098377

Eighty patients with carcinoma in the middle third of oesophagus and with acute radiation oesophagitis following external beam and intracavitary radiotherapy were managed by two different schedules. Group 1 (n = 40) received an antacid containing sodium alginate whereas Group 2 (n = 40) were given a 10% sucralfate suspension during 4 weeks. In Group 2, 32 patients had significant relief of symptoms within 7 days of treatment and most ulcers had healed by 12 days of treatment as seen on endoscopy. Patients in Group 1, on the other hand, showed little improvement of symptoms and had persistent ulcers even after 4 weeks of therapy. We conclude that sucralfate is useful in the management of acute radiation oesophagitis.