Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that catalyzes the kynurenine (Kyn) pathway of tryptophan metabolism in the first step, and the kynurenine pathway plays a fundamental role in immunosuppression in the tumor microenvironment. Therefore, researchers are vigorously develo...

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Published inEuropean journal of medicinal chemistry Vol. 238; p. 114524
Main Authors Zhang, Ya, Hu, Zelin, Zhang, Jifa, Ren, Changyu, Wang, Yuxi
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 05.08.2022
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Summary:Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that catalyzes the kynurenine (Kyn) pathway of tryptophan metabolism in the first step, and the kynurenine pathway plays a fundamental role in immunosuppression in the tumor microenvironment. Therefore, researchers are vigorously developing IDO1 inhibitors, hoping to apply them to cancer immunotherapy. Nowadays, there have been 11 kinds of IDO1 inhibitors entering clinical trials, among which many inhibitors have shown good tumor inhibitory effect in phase I/II clinical trials. But the phase III study of the most promising IDO1 inhibitor compound 29 (Epacadostat) failed in 2018, which may be caused by the compensation effect offered by tryptophan 2,3-dioxygenase (TDO), the mismatched drug combination strategies, or other reasons. Luckily, dual-target inhibitors show great potential and advantages in solving these problems. In recent years, many studies have linked IDO1 to popular targets and selected many IDO1 dual-target inhibitors through pharmacophore fusion strategy and library construction, which enhance the tumor inhibitory effect and reduce side effects. Currently, three kinds of IDO1/TDO dual-target inhibitors have entered clinical trials, and extensive studies have been developing on IDO1 dual-target inhibitors. In this review, we summarize the IDO1 dual-target inhibitors developed in recent years and focus on the structure optimization process, structure-activity relationship, and the efficacy of in vitro and in vivo experiments, shedding a light on the pivotal significance of IDO1 dual-target inhibitors in the treatment of cancer, providing inspiration for the development of new IDO1 dual-target inhibitors. [Display omitted] •IDO1 catalyzes the kynurenine pathway of tryptophan metabolism, which plays a crucial role in immunosuppression in the tumor microenvironment.•While the efficacy of IDO1 inhibitors in cancer treatment is not ideal hitherto, the dual-target inhibitors of IDO1 have greater therapeutic potential.•Summary of the latest research progress of IDO1 dual-target inhibitors.•Presenting the extremely high development value of IDO1 dual-target inhibitors in cancer immunotherapy.
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ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2022.114524