Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1β and IL-6 Levels

Oral mucositis (OM) is the oral inflammation as manifestation of chemotherapy and/or radiotherapy. Cinnamomum osmophloeum (CO), of which the constituents possess anti-inflammatory activities, may have potential to alleviate OM. In this study, laboratory rats were injected with 5-Fluororacil and thei...

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Bibliographic Details
Published inProcesses Vol. 9; no. 4; p. 615
Main Authors Bakar, Abu, Ningrum, Valendriyani, Lee, Shih-Chieh, Li, Chi-Ting, Hsieh, Chang-Wei, Wang, Sue-Hong, Tsai, Ming-Shun
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.04.2021
Subjects
Body weight
Carbon monoxide
Chemotherapy
Cinnamomum osmophloeum
Cytokines
Ethanol
Experiments
Food
IL-1β
Inflammation
Interleukin 6
Laboratory animals
Leaves
Mucosa
Mucositis
Plant extracts
Radiation therapy
Sodium
Triamcinolone acetonide
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Water intakes
United States > US
Taiwan
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Summary:Oral mucositis (OM) is the oral inflammation as manifestation of chemotherapy and/or radiotherapy. Cinnamomum osmophloeum (CO), of which the constituents possess anti-inflammatory activities, may have potential to alleviate OM. In this study, laboratory rats were injected with 5-Fluororacil and their oral mucosa were irritated by 18-gauge needle pouching to induce OM. Rats were randomly divided into six experimental groups: without treatment (WT), only 100 mg/mL CO leaf extract (COLE) treatment (100-only), only 5-Fluororacil treatment (5-FU), 5-FU then treated with Triamcinolone acetonide orobase (5-FU+G), 5-FU then treated with 50 mg/mL COLE, and 5-FU then treated with 100 mg/mL COLE (5-FU+100). Body weights and food and water intakes during the experimental period were recorded. Macroscopic examination, histopathological analyses, and serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels of these rats were evaluated or determined. No significant difference was found between the WT and 100-only groups. Results of macroscopic examinations, histopathological analyses, body weight changes, food and water intakes, and serum IL-1β and IL-6 levels showed significant therapeutic effects of the 5-FU+100 group compared to the 5-FU group. These finding suggest that COLE can be one of potential remedies for OM therapy through influencing proinflammatory cytokine levels.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr9040615