Use of finer needles for venipuncture increases in vitro haemolysis despite reducing persistent pain and nerve injury: A retrospective study

• Published in: Annals of clinical biochemistry Vol. 61; no. 2; p. 107
• Main Authors: Umemura, Hiroshi, Takahashi, Hiromichi, Fukuda, Yoshiaki, Soma, Hitoshi, Aoki, Rumiko, Takei, Norihisa, Nakayama, Tomohiro
• Format: Journal Article
• Language: English
• Published: England 01.03.2024
• Subjects: Aspartate Aminotransferases; Hemolysis; Humans; Lactate Dehydrogenases; Neuralgia; Phlebotomy - adverse effects; Potassium; Retrospective Studies; haemolysis index; venipuncture; neuropathic pain; Haemolysis; persistent pain
• ISSN: 1758-1001
• DOI: 10.1177/00045632231196045

Although venipuncture is minimally invasive, and is the most frequently performed medical procedure, it carries the small risk of causing persistent pain, including nerve damage. Recently, our hospital stopped using 22-gauge needles for venipuncture in outpatients and switched to using only 23- and 25-gauge needles. We investigated the impact of using only the finer needles on the incidence of persistent or neuropathic pain and the prevalence of haemolysis, as well as the impact of haemolysis associated with the needle change on other laboratory data. We retrospectively collected and analysed data on venipuncture-associated pain complaints made during the 1-year period prior and 1-year period after the change in needles, as well as the frequency of haemolysis before and after the change. We also focused on 90 cases that showed significant haemolysis after the needle change and compared the serum aspartate aminotransferase, lactate dehydrogenase, and potassium levels before and after the needle change. The incidence of persistent pain was significantly reduced from 1 in 10,825 venipunctures before the change to 1 in 29,747 venipunctures after the change. Notably, no patients experienced neuropathic pain after the change. However, the prevalence of haemolysis was significantly increased. Additionally, the serum aspartate aminotransferase, lactate dehydrogenase, and potassium levels were significantly elevated in the cases that showed moderate to gross haemolysis after the needle change. Using finer needles involves both advantages and disadvantages, and careful consideration is needed to determine which type of needle is in the best interests of the patient.