Response to Melatonin Treatment in Children With Autism spectrum Disorder and Relationship to Sleep Parameters and Melatonin Levels

• Published in: Journal of child neurology Vol. 38; no. 5; p. 253
• Main Authors: Martinez-Cayuelas, Elena, Merino-Andreu, Milagros, Losada-Del Pozo, Rebeca, Gavela-Pérez, Teresa, Garcés, Carmen, Soriano-Guillén, Leandro
• Format: Journal Article
• Language: English
• Published: United States 01.04.2023
• Subjects: Adolescent; Autism Spectrum Disorder - complications; Autism Spectrum Disorder - drug therapy; Child; Circadian Rhythm - physiology; Humans; Melatonin - therapeutic use; Sleep - physiology; Treatment Outcome; sleep; temperature; actigraphy; autism spectrum disorder; melatonin; circadian rhythm
• ISSN: 1708-8283
• DOI: 10.1177/08830738231173606

Melatonin is one of the most used pharmacologic treatments for sleep problems in autism spectrum disorder, though its relationship with circadian and sleep parameters is still not well stablished. A naturalistic study was conducted in children with autism spectrum disorder, previously drug-naïve, before and after treatment with immediate-release melatonin. Circadian rhythms and sleep parameters were studied using an ambulatory circadian-monitoring device, and saliva samples were collected enabling determination of dim light melatonin onset. Twenty-six children with autism spectrum disorder (age 10.50  ±  2.91) were included. Immediate-release melatonin modified circadian rhythm as indicated by wrist skin temperature, showing an increase at night. A positive correlation was found between time of peak melatonin and sleep efficiency improvement values. Sleep-onset latency and efficiency improved with immediate-release melatonin. Immediate-release melatonin could be an effective treatment to improve sleep onset and restore a typical pattern of wrist temperature, which appears to be lost in autism spectrum disorder.