Treatment of vascular leg ulcers with leukocyte- and platelet-rich fibrin (L-PRF): A systematic review

This systematic review aimed to assess the efficacy of Leukocyte- and Platelet-Rich Fibrin (L-PRF) for the treatment of vascular leg ulcers. Following PRISMA guidelines, a literature search was done for studies where L-PRF was used to treat vascular leg ulcers. Among six included articles, a total o...

Full description

Saved in:
Bibliographic Details
Published inPhlebology p. 2683555241256543
Main Authors Barzegar Amin, Amirali, Dorpmans, Dries, Mufty, Hozan, Fourneau, Inge
Format Journal Article
LanguageEnglish
Published England 01.09.2024
Subjects
leg ulcer
wound healing
Platelet-rich fibrin
Online AccessGet more information

Cover

More Information
Summary:This systematic review aimed to assess the efficacy of Leukocyte- and Platelet-Rich Fibrin (L-PRF) for the treatment of vascular leg ulcers. Following PRISMA guidelines, a literature search was done for studies where L-PRF was used to treat vascular leg ulcers. Among six included articles, a total of 76 venous leg ulcers were treated with L-PRF. None of the studies included ulcers of arterial or lymphatic origin. Fifty-seven (75.0%) of the venous ulcers completely healed at end of follow-up. Mean time to complete healing was 6.7 weeks (SD = 5.0). All non-healed ulcers showed an important reduction in wound area. No adverse effects related to L-PRF therapy were reported. The results suggest that L-PRF could be a safe, simple to use and effective therapeutic option for the treatment of venous leg ulcers, however, caution is advised as the results are based on small sample sizes.
ISSN:1758-1125
DOI:10.1177/02683555241256543