Biological Role of the 3β-Corner Structural Motif in Proteins

• Published in: Processes Vol. 10; no. 11; p. 2159
• Main Authors: Rudnev, Vladimir R, Petrovsky, Denis V, Nikolsky, Kirill S, Kulikova, Liudmila I, Stepanov, Alexander A, Malsagova, Kristina A, Kaysheva, Anna L, Efimov, Alexander V
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022
• Subjects: Alzheimer's disease; Amino acids; Analysis; Clustering; Polypeptides; Proteins; Severe acute respiratory syndrome coronavirus 2; Structure-function relationships
• ISSN: 2227-9717; 2227-9717
• DOI: 10.3390/pr10112159

In this study, we analyze the occurrence of the unique structural motif, the 3β-corner, belonging to the Structural Classification of Proteins (SCOP) folds, in proteins of various origins. We further assess the structural and functional role of this motif as well as the clustering of the biological functions of proteins in which it occurs. It has been shown previously that the 3β-corner occurs with different probabilities in all beta proteins, alpha and beta proteins (α + β and α/β), and alpha classes occur most often in the composition of β-proteins. The 3β-corner is often found as a building block in protein structures, such as β-barrels, -sandwiches, and -sheets/-layers.