Transition metal( ii ) complexes of halogenated derivatives of ( E )-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline: structure, antioxidant activity, DNA-binding DNA photocleavage, interaction with albumin and in silico studies

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 43; pp. 16688 - 16705
• Main Authors: Kakoulidou, Chrisoula, Chasapis, Christos T., Hatzidimitriou, Antonios G., Fylaktakidou, Konstantina C., Psomas, George
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 08.11.2022
• Subjects: Biological activity; Cadmium; Cattle; Copper; Crystallography; Hydrogen peroxide; Manganese; Methylene; Molecular docking; Nickel; Plasmids; Serum albumin; Single crystals; Sulfonic acid; Transition metals; Zinc
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/d2dt02622h

Two novel halogenated (Br- and F-) quinazoline derivatives, namely [( E )-4-(2-((6-bromopyridin-2-yl)methylene)hydrazinyl)quinazoline] (L1) and [( E )-4-(2-((3-fluoropyridin-2-yl)methylene)hydrazinyl) quinazoline] (L2), were synthesized and characterized. Their interaction with a series of metal( ii ) ions (= Mn( ii ), Ni( ii ), Cu( ii ), Zn( ii ) and Cd( ii )) resulted in the formation of six mononuclear complexes characterized by spectroscopic techniques and single-crystal X-ray crystallography. The complexes bear the formulae [Ni(L 1 ) 2 ](NO 3 ) 2 (1), [Zn(L 2 ) 2 ](NO 3 )(PF 6 ) (2), [Cd(L 2 )(H 2 O)(CH 3 OH)(NO 3 )](NO 3 ) (3), [Cu(L 2 )Cl 2 ] (4), [Ni(L 2 ) 2 ](NO 3 ) 2 (5) and [Mn(L 2 )(CH 3 OH)(Cl) 2 ] (6). The biological activity of the compounds was further evaluated in vitro regarding their interaction with calf-thymus DNA, their cleavage ability towards supercoiled circular pBR322 plasmid DNA in the absence or presence of irradiation at various wavelengths (UVA, UVB and visible light), their affinity to bovine serum albumin and their ability to scavenge 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals and to reduce H 2 O 2 . In silico molecular docking calculations were employed to study the behavior of the complexes towards calf-thymus DNA and bovine serum albumin.