Macromolecular microfluidic concentrators

Microfluidic design, fabrication, and experiments have developed rapidly, leading to lab-on-chip separation or fractionation. In this work, we design a continuous concentrator for macromolecular solutions. Our design relies on the analytical solutions for orientational diffusion under laminar pressu...

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Bibliographic Details
Published inPhysics of fluids (1994) Vol. 34; no. 10
Main Authors Coombs, S. J., Tontiwattanakul, K., Giacomin, A. J.
Format Journal Article
LanguageEnglish
Published Melville American Institute of Physics 01.10.2022
Subjects
Concentrators
Confinement
Design analysis
Dilution
Exact solutions
Fractionation
Laminar flow
Macromolecules
Microchannels
Microfluidics
Separation
Shear rate
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Summary:Microfluidic design, fabrication, and experiments have developed rapidly, leading to lab-on-chip separation or fractionation. In this work, we design a continuous concentrator for macromolecular solutions. Our design relies on the analytical solutions for orientational diffusion under laminar pressure-driven slot flow through a microchannel [W. Stasiak and C. Cohen, “Dilute solutions of macromolecules in a rectilinear Poiseuille flow,” J. Chem. Phys. 78, 553 (1983)]. Using rigid dumbbell theory, we provide analytical solutions for the design of our microfluidic macromolecular hydrodynamic chromatography. We arrive at our design through the use of well-known confinement-driven composition profiles. Using a pair of razor-sharp blades, our design separates the slot flow into a symmetric core inner slot (concentrated) between two outer slots (diluted). We discover a minimum dimensionless blade leading edge separation for complete fractionation, and that this decreases with confinement and also decreases with dimensionless shear rate.
ISSN:1070-6631
1089-7666
DOI:10.1063/5.0116830