Ouabain induces apoptosis on PHA-activated lymphocytes

Apoptotic cell death plays a critical role in immune system homeostasis, and c-myc protooncogene deregulated expression is a component of this programmed genomic response. Pharmacological intervention and modulation of peripheral lymphocytes apoptosis would have important implications. The present r...

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Bibliographic Details
Published inBioscience reports Vol. 18; no. 1; pp. 1 - 7
Main Authors Olej, B, dos Santos, N F, Leal, L, Rumjanek, V M
Format Journal Article
LanguageEnglish
Published England 01.02.1998
Subjects
Apoptosis
Cell Division
Cytoplasm - metabolism
DNA Fragmentation
Enzyme Inhibitors - pharmacology
Gene Expression
Humans
Lymphocyte Activation
Lymphocytes - cytology
Lymphocytes - drug effects
Lymphocytes - metabolism
Ouabain - pharmacology
Phytohemagglutinins - pharmacology
Proto-Oncogene Proteins c-myc - biosynthesis
Proto-Oncogene Proteins c-myc - genetics
RNA, Messenger
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Summary:Apoptotic cell death plays a critical role in immune system homeostasis, and c-myc protooncogene deregulated expression is a component of this programmed genomic response. Pharmacological intervention and modulation of peripheral lymphocytes apoptosis would have important implications. The present results indicate that ouabain, a specific inhibitor of Na+K(+)-ATPase, promotes an increased expression of c-myc mRNA, and induces apoptosis in PHA-stimulated lymphocytes. Furthermore, this ouabain-induced apoptosis cannot be counteracted by the addition of exogenous IL-2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0144-8463
1573-4935
DOI:10.1023/A:1022259832207