Effects of prolactin on DNA synthesis, cholesterol stores, and steroidogenesis in the adrenal cortex of dexamethasone-treated guinea pigs

The effect of prolactin on the guinea pig adrenal cortex is studied in a model of dexamethasone-induced atrophy. Prolactin elevates the content of free and total cholesterol per tissue weight but does not affect the specific activity of hydrocortisone synthesized in the presence of labeled cholester...

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Published inBulletin of experimental biology and medicine Vol. 123; no. 1; pp. 14 - 16
Main Authors Sautin, Yu. Yu, Kovzun, E. I., Tron’ko, N. D., Mikosha, A. S.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.01.1997
Subjects
Adrenal cortex
Adrenal glands
Animal models
Atrophy
Cholesterol
Deoxyribonucleic acid
DNA
DNA biosynthesis
Hydrocortisone
Prolactin
Steroidogenesis
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Summary:The effect of prolactin on the guinea pig adrenal cortex is studied in a model of dexamethasone-induced atrophy. Prolactin elevates the content of free and total cholesterol per tissue weight but does not affect the specific activity of hydrocortisone synthesized in the presence of labeled cholesterol. It is concluded that prolactin has no direct effect on hormonopoiesis but activates proliferative processes in the adrenal cortex.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02764366