Double hit – A case in point for dual seropositivity to AQP4 and MOG antibodies

AQP4-IgG NMOSD (anti-aquaporin-4 neuromyelitis optica spectrum disorder) and MOGAD (myelin oligodendrocyte glycoprotein antibody associated disease) are unique disorders among themselves, with rare reports of dual seropositivity being described. Evaluation with cell-based assays reduces the incidenc...

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Bibliographic Details
Published inJournal of neuroimmunology Vol. 383; p. 578198
Main Authors Jain, Kshiteeja, Anita, M., Netravathi, M.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.10.2023
Subjects
AQP4
Dual
LETM
MOG
Myelitis
NMOSD
Seropositive
Myelitis
LETM
MOG
AQP4
Dual
Seropositive
NMOSD
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Summary:AQP4-IgG NMOSD (anti-aquaporin-4 neuromyelitis optica spectrum disorder) and MOGAD (myelin oligodendrocyte glycoprotein antibody associated disease) are unique disorders among themselves, with rare reports of dual seropositivity being described. Evaluation with cell-based assays reduces the incidence of false positivity. The clinical features of these cases may either have a dominant phenotype or may evolve into one subsequently. We describe a young girl aged 18-year-old who presented with longitudinally extensive transverse myelitis and dual seropositivity to both AQP4 and MOG antibodies. •Dual seropositivity of AQP4 and MOG – antibody is a rare phenomenon.•Dual seropositivity is noticed to be common in females with predilection to cause either Optic neuritis or LETM.•Dual seropositivity may result in double strike resulting in poor prognosis.
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ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2023.578198