Acyclic cucurbit[ n ]uril-based nanosponges significantly enhance the photodynamic therapeutic efficacy of temoporfin in vitro and in vivo

Acyclic cucurbit[ n ]uril-based nanosponges are prepared based on supramolecular vesicle-templated cross-linking. The nanosponges are capable of encapsulating the clinically approved photodynamic therapeutic (PDT) drug temoporfin. When loaded with nanosponges, the PDT bioactivity of temoporfin is en...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 11; no. 37; pp. 9027 - 9034
Main Authors Zhao, Zizhen, Yang, Jingyu, Liu, Yamin, Wang, Shuyi, Zhou, Wei, Li, Zhan-Ting, Zhang, Dan-Wei, Ma, Da
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 27.09.2023
Subjects
Biocompatibility
Biological activity
Cancer
Confocal microscopy
Crosslinking
Effectiveness
Flow cytometry
Scanning microscopy
Tumor suppression
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Summary:Acyclic cucurbit[ n ]uril-based nanosponges are prepared based on supramolecular vesicle-templated cross-linking. The nanosponges are capable of encapsulating the clinically approved photodynamic therapeutic (PDT) drug temoporfin. When loaded with nanosponges, the PDT bioactivity of temoporfin is enhanced 7.5-fold for HeLa cancer cells and 20.8 fold for B16-F10 cancer cells, respectively. The reason for the significant improvement in PDT efficacy is confirmed to be an enhanced cell uptake by confocal laser scanning microscopy and flow cytometry. Animal studies show that nanosponges could dramatically increase the tumor suppression effect of temoporfin. In vitro and in vivo experiments demonstrate that nanosponges are nontoxic and biocompatible.
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ISSN:2050-750X
2050-7518
DOI:10.1039/d3tb01422c