Neurovascular patterning cues and implications for central and peripheral neurological disease

The highly branched nervous and vascular systems run along parallel trajectories throughout the human body. This stereotyped pattern of branching shared by the nervous and vascular systems stems from a common reliance on specific cues critical to both neurogenesis and angiogenesis. Continually emerg...

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Bibliographic Details
Published inSurgical neurology international Vol. 8; no. 1; p. 208
Main Authors Gamboa, Nicholas, Taussky, Philipp, Park, Min, Couldwell, William, Mahan, Mark, Kalani, M
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer India Pvt. Ltd 01.01.2017
Medknow Publications & Media Pvt Ltd
Subjects
Neurovascular: Review
neurogenesis
Angiogenesis
axon guidance
neurosurgery
vascular endothelial growth factor
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Summary:The highly branched nervous and vascular systems run along parallel trajectories throughout the human body. This stereotyped pattern of branching shared by the nervous and vascular systems stems from a common reliance on specific cues critical to both neurogenesis and angiogenesis. Continually emerging evidence supports the notion of later-evolving vascular networks co-opting neural molecular mechanisms to ensure close proximity and adequate delivery of oxygen and nutrients to nervous tissue. As our understanding of these biologic pathways and their phenotypic manifestations continues to advance, identification of where pathways go awry will provide critical insight into central and peripheral nervous system pathology.
ISSN:2152-7806
2229-5097
2152-7806
DOI:10.4103/sni.sni_475_16