Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts
Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin （HA） genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in...
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| Published in | Virologica Sinica Vol. 24; no. 1; pp. 65 - 70 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Heidelberg
SP Wuhan Institute of Virology, CAS
01.02.2009
Institute of Life Sciences, Taishan Medical College, Taian 271000, China%Department of Basic Medicine, Taishan Medical College, Taian 271000, China%Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract | Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin （HA） genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses. |
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| AbstractList | Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses. R373; Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses. Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin （HA） genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses. |
| Author | Wei-feng SHI Ai-she DUN Zhong ZHANG Yan-zhou ZHANG Guang-fu YU Dong-ming ZHUANG Chao-dong ZHU |
| AuthorAffiliation | Institute of Life Sciences, Taishan Medical College, Taian 271000, China Department of Basic Medicine, Taishan Medical College, Taian 271000, China Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
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| Cites_doi | 10.1073/pnas.88.10.4270 10.1073/pnas.96.16.9363 10.1128/JVI.77.5.3148-3156.2003 10.1007/s00705-007-1083-1 10.1073/pnas.91.18.8388 10.1016/0042-6822(85)90131-X 10.1099/vir.0.81397-0 10.1093/molbev/msi105 10.1371/journal.pcbi.0020062 10.1093/bioinformatics/bti079 10.1128/JVI.78.16.8609-8614.2004 10.1016/j.virol.2005.02.003 10.1006/viro.2000.0799 10.1016/j.virol.2005.08.032 10.1016/j.virusres.2003.12.032 10.1080/10635150390235520 10.3201/eid1012.040759 10.1128/MMBR.56.1.152-179.1992 10.1093/genetics/155.1.431 10.1093/oxfordjournals.molbev.a026057 |
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| Keywords | Avian influenza virus Selection pressure Haemagglutinin R373 H9N2 |
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| Title | Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts |
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