Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts

• Published in: Virologica Sinica Vol. 24; no. 1; pp. 65 - 70
• Main Authors: Shi, Wei-feng, Dun, Ai-she, Zhang, Zhong, Zhang, Yan-zhou, Yu, Guang-fu, Zhuang, Dong-ming, Zhu, Chao-dong
• Format: Journal Article
• Language: English; Chinese
• Published: Heidelberg SP Wuhan Institute of Virology, CAS 01.02.2009; Institute of Life Sciences, Taishan Medical College, Taian 271000, China%Department of Basic Medicine, Taishan Medical College, Taian 271000, China%Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Medical Microbiology; Microbial Genetics and Genomics; Microbiology; Oncology; Virology; 治疗方法; 流感病毒; 血凝素; 预防措施; Avian influenza virus; Selection pressure; Haemagglutinin; R373; H9N2
• ISSN: 1674-0769; 1995-820X
• DOI: 10.1007/s12250-009-2988-5

Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin （HA） genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses.