Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts
Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in...
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Published in | Virologica Sinica Vol. 24; no. 1; pp. 65 - 70 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English Chinese |
Published |
Heidelberg
SP Wuhan Institute of Virology, CAS
01.02.2009
Institute of Life Sciences, Taishan Medical College, Taian 271000, China%Department of Basic Medicine, Taishan Medical College, Taian 271000, China%Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
Subjects | |
Online Access | Get full text |
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Summary: | Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses. |
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Bibliography: | H9N2 H9N2; Avian influenza virus; Haemagglutinin; Selection pressure 42-1760/Q Avian influenza virus Selection pressure S855.3 Haemagglutinin S852.659.5 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1674-0769 1995-820X |
DOI: | 10.1007/s12250-009-2988-5 |