Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm 2 Using Intravascular Ultrasound)

• Published in: Korean circulation journal Vol. 44; no. 3; pp. 148 - 155
• Main Authors: Hong, Young Joon, Choi, Yun Ha, Park, Soo Young, Nam, Chang Wook, Cho, Jang Hyun, Kang, Won Yu, Lee, Sang Rok, Lee, Sung Yun, Kim, Sang Wook, Lim, Sang Yeob, Yun, Kyung Ho, Kim, Jung Sun, Kim, Jin Won, Kang, Woong Chol, Kim, Ki Seok, Choi, Jin Ho, Chung, Joong Wha, Kim, Soo Joong, Ahn, Youngkeun, Jeong, Myung Ho
• Format: Journal Article
• Language: English
• Published: The Korean Society of Cardiology 01.05.2014; 대한심장학회
• Subjects: Original; 내과학
• ISSN: 1738-5520; 1738-5555
• DOI: 10.4070/kcj.2014.44.3.148

Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30–70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm2 with 50–70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43–6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24–5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18–5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50–70% of plaque burden. KCI Citation Count: 2