New potent and selective A1 adenosine receptor agonists

Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosine receptor agonists. Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosine receptor agonists.

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 12; no. 18; pp. 4877 - 4884
Main Authors Hutchinson, Sally A., Baker, Stephen P., Linden, Joel, Scammells, Peter J.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 15.09.2004
Elsevier Science
Subjects
A1 adenosine receptor (A1AR)
Adenosine
Adenosine A1 Receptor Agonists
Agonist
Animals
Biological and medical sciences
Cricetinae
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
PC12 Cells
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Rats
Sulfides - chemistry
Sulfides - pharmacology
A1 adenosine receptor (A1AR)
Adenosine
Agonist
Sulfur heterocycle
Purine nucleoside
Structure activity relation
A1 Adenosine receptor
Affinity
Selectivity
Tricyclic compound
Episulfide
Ribonucleoside
Chemical synthesis
In vitro
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Summary:Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosine receptor agonists. Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosine receptor agonists.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2004.07.004