Comparison of two dissolution apparatuses with correlation of in vitro-in vivo data for prednisone and prednisolone tablets

Dissolution profiles in 0.1N hydrochloric acid using both the paddle stirrer apparatus and the spin filter apparatus were obtained for prednisone tablets made by seven different manufacturers and prednisolone tablets made by eight different manufacturers. Dissolution parameters were correlated with...

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Bibliographic Details
Published inBiopharmaceutics & drug disposition Vol. 1; no. 1; p. 3
Main Authors Milsap, R L, Ayres, J W, Mackichan, J J, Wagner, J G
Format Journal Article
LanguageEnglish
Published England 01.07.1979
Subjects
Biological Availability
Chemistry, Pharmaceutical - instrumentation
Humans
Male
Prednisolone - administration & dosage
Solubility
Tablets
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Summary:Dissolution profiles in 0.1N hydrochloric acid using both the paddle stirrer apparatus and the spin filter apparatus were obtained for prednisone tablets made by seven different manufacturers and prednisolone tablets made by eight different manufacturers. Dissolution parameters were correlated with results obtained in three human bioavailability trials which were previously reported. Also, results obtained in one apparatus were correlated with those obtained in the other apparatus. Such correlations may be useful in the setting of in vitro dissolution rate specifications for commerical prednisone and prednisolone tablets.
ISSN:0142-2782
DOI:10.1002/bdd.2510010103