A Case report of suicide in a teenager with long-term use of fluoxetine associated with CYP2D6 Polymorphism

Conclusions Fluoxetine use may cause toxic drug accumulation thus leading to worsening of suicidal thoughts if taken by teenagers with possible genetic determined insufficiency of CYP2D6 enzyme (poor metabolizer).

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Bibliographic Details
Published inClinical therapeutics Vol. 37; no. 8; p. e95
Main Authors Asriyants, S.V, Veselkina, O.V, Sychev, D.A, Obuhova, Y.D, Polyakov, A.V, Klevno, V.A
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2015
Elsevier Limited
Subjects
Antidepressants
Enzymes
Internal Medicine
Medical Education
Suicides & suicide attempts
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Summary:Conclusions Fluoxetine use may cause toxic drug accumulation thus leading to worsening of suicidal thoughts if taken by teenagers with possible genetic determined insufficiency of CYP2D6 enzyme (poor metabolizer).
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.272