The Association of the rs2108622 Single Nucleotide Polymorphism in the CYP4F2 Gene with Resistance to Clopidogrel

The aim of the study was to determine the impact of carriership of at least one CYP4F2*3 allele on the risk of resistance to clopidogrel in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Results Pharmacogenetic testing showed that 40 (49,4%) of AC...

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Bibliographic Details
Published inClinical therapeutics Vol. 39; no. 8; p. e62
Main Authors Konova, O.D, Mirzaev, K.B, Ryzhikova, K.A, Sozaeva, Zh.A, Andreev, D.A, Sychev, D.A
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2017
Elsevier Limited
Subjects
Acute coronary syndromes
Clopidogrel
Gene polymorphism
Genotype & phenotype
Internal Medicine
Intervention
Medical Education
Patients
Pharmacology
Polymorphism
Single-nucleotide polymorphism
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Summary:The aim of the study was to determine the impact of carriership of at least one CYP4F2*3 allele on the risk of resistance to clopidogrel in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Results Pharmacogenetic testing showed that 40 (49,4%) of ACS patients had normal...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.192