Lead Generation of Anti-allergic Agent ; Suplatast Tosilate

The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds fr...

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Bibliographic Details
Published inChem-Bio Informatics Journal Vol. 1; no. 1; pp. 51 - 59
Main Authors Tada, Yukio, Yamawaki, Ichiro, Ueda, Shu-ichi, Matsumoto, Hiroshi, Matsuura, Naosuke, Yasumoto, Mitsugi, Koda, Akihide, Hori, Mikio
Format Journal Article
LanguageJapanese
English
Published Tokyo Chem-Bio Informatics Society 2001
Japan Science and Technology Agency
Subjects
Suplatast Tosialate; Sulfonium Compound; Antiallergy Drug; Ion Pairs; Transport Rate
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Summary:The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds from the point of structure activity relationships analysis in order to develop an antiallergy drug. We found that several sulfonium compounds have immunological activity, and 2-hydroxyethyldimethylsulfonium p-toluenesulfonate (4) was chosen as the lead compound for further studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1347-6297
1347-0442
DOI:10.1273/cbij.1.51