Potential Antimetabolites. III. Synthesis of 5-Aminoimidazole-4-carboxthioamide and Nitro-1-β-D-ribofuranosylimidazoles

5-Aminoimidazole-4-carboxthioamide was synthesized by the phosphorus pentasulfide-pyridine treatment of 5-aminoimidazole-4-carboxamide. The structure was elucidated both by chemical and physical means. 1-β-D-Ribofuranosy1-4-methyl-5-nitroimidazole and 1-β-D-ribofuranosy1-4-nitro-5-methoxycarbonylimi...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 10; no. 8; pp. 660 - 664
Main Authors Nakazawa, Nobuhiko, Nakayama, Hiroshi, Ikehara, Morio
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.08.1962
Subjects
Antimetabolites
Imidazoles
OldMedline
ANTIMETABOLITES
IMIDAZOLES
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.10.660

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Summary:5-Aminoimidazole-4-carboxthioamide was synthesized by the phosphorus pentasulfide-pyridine treatment of 5-aminoimidazole-4-carboxamide. The structure was elucidated both by chemical and physical means. 1-β-D-Ribofuranosy1-4-methyl-5-nitroimidazole and 1-β-D-ribofuranosy1-4-nitro-5-methoxycarbonylimidazole were synthesized by the condensation of appropriate imidazole chloro-mercury salt with 2, 3, 5-tri-Obenzoyl-D-ribofuranosyl chloride followed by the removal of protecting groups.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.10.660