Significant Performance Improvement of MicroRNA-375 Detection by Modulation of Au Nanoparticle Distribution Using Silicon-on-Insulator MOSFET

Using silicon-on-insulator MOSFET as the platform for RNA detection, the impact of Au nanoparticle (AuNP) distribution on sensitivity is investigated in this work. For the first time it is revealed that the AuNP formed by 2 nm as-deposited Au film (AuNP (2nm)) enables the largest amount of effective...

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Bibliographic Details
Published inIEEE electron device letters Vol. 43; no. 1; pp. 128 - 130
Main Authors Wang, Haihua, Xiao, Kai, Jiang, Yu-Long, Wan, Jing
Format Journal Article
LanguageEnglish
Published New York IEEE 01.01.2022
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
AuNP
BG-MOSFET
biosensor
Biosensors
DNA
Fluorescence
Gold
MicroRNA-375
MicroRNAs
MOSFET
MOSFETs
Nanoparticles
Probes
Ribonucleic acid
RNA
Sensitivity
Silicon
SOI
SOI (semiconductors)
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Summary:Using silicon-on-insulator MOSFET as the platform for RNA detection, the impact of Au nanoparticle (AuNP) distribution on sensitivity is investigated in this work. For the first time it is revealed that the AuNP formed by 2 nm as-deposited Au film (AuNP (2nm)) enables the largest amount of effective immobilization probe DNA, which enhances the capture efficiency of target microRNA-375, thus improving the sensitivity by 55% and 100%, compared to AuNP (1 nm) and AuNP (3 nm) case, respectively. It provides a new way to improve the microRNA detection sensitivity for sensors in which Au is used as the linker based on FET platform.
ISSN:0741-3106
1558-0563
DOI:10.1109/LED.2021.3129347