Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

• Published in: Anadolu psikiyatri dergisi Vol. 19; no. 2; pp. 135 - 142
• Main Authors: Baykan, Hayriye, Durmaz, Onur, Baykan, Özgür, Alışık, Murat, Can, Merve, Karlıdere, Tunay, Erel, Özcan
• Format: Journal Article
• Language: English
• Published: Sivas ESFORM Ofset Ltd 01.01.2018; Anatolian Journal of Psychiatry
• Subjects: Alzheimer's disease; Antioxidants; Anxiety; Cardiovascular disease; Cognitive ability; Enzymes; Felsefe & Psikoloji & Sosyoloji; Homeostasis; Mental depression; Metabolism; Neurobiology; Oxidation; Oxidative stress; Patients; Psychiatry; Studies; Systemic diseases; Womens health; Sivas; Türkiye; thiol; disülfid; disulphide; tiyol; oksidatif stres; kadın; depression; female; Depresyon; oxidative stress
• ISSN: 1302-6631
• DOI: 10.5455/apd.275045

Objective: We aimed to investigate the oxidative stress status in a population of women with untreated major depressive disorder. Methods: Fifty-four female patients with untreated major depressive disorder and 68 female healthy controls were included in the study. A Sociodemographic Form, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale (HAM-D) were applied to all the participants. Fasting blood samples were collected from all participants to assess serum thiol/disulphide levels and their pairwise ratios. Results: Native thiol levels were significantly higher and disulphide levels were lower in patients as compared to controls, while total thiol levels were not significantly different between the groups. Disulphide/native thiol and disulphide/total thiol ratios were significantly lower, while the native thiol/total thiol ratio was significantly higher, in the patient group than the control group. There was a negative correlation between HAM-D score and disulphide level, disulphide/native thiol ratio, and disulphide/total ratio, while there was a positive correlation between HAM-D score and native/total thiol ratio, in the patient group. Discussion: This is the first study to investigate dynamic thiol/disulphide homeostasis in women with untreated major depressive disorder. Our results showed dynamic thiol/disulphide homeostasis shifts towards thiol formation which implies an antioxidant reaction in women with untreated major depressive disorder.