Sclareol: Isolation, Structural Modification, Biosynthesis, and Pharmacological Evaluation – A Review

Sclareol, isolated from a variety of plant species like Salvia sclarea , is a labdane diterpene of high value for the flavour and fragrance industries. Sclareol is biosynthetically produced through the methylerythritol-phosphate (MEP) pathway. It is a nontoxic molecule used as a topical and oral pro...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 57; no. 10; pp. 1568 - 1579
Main Authors Jameel, Salman, Bhat, Khursheed Ahmad
Format Journal Article
LanguageEnglish
Published New York Springer US 2024
Subjects
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
sclareol
antibacterial
diterpene
anticancer
biosynthesis
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Summary:Sclareol, isolated from a variety of plant species like Salvia sclarea , is a labdane diterpene of high value for the flavour and fragrance industries. Sclareol is biosynthetically produced through the methylerythritol-phosphate (MEP) pathway. It is a nontoxic molecule used as a topical and oral product. This bicyclic diterpene alcohol is a key starting natural product for the preparation of the high-value perfume ingredient ambroxide. A number of research studies regarding sclareol chemistry, biosynthesis and pharmacological activities are reported in the literature. The present review is an attempt to compile the different aspects of sclareol. The review presents the occurrence, biosynthesis, pharmacological properties and structural modifications of sclareol.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-024-03050-z