Role of the mitochondrial ATP-sensitive K+ channels in cardioprotection

The mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoK(ATP). These and other studies have also suggested that mitoK(ATP) plays...

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Published inActa biochimica polonica Vol. 51; no. 2; pp. 379 - 390
Main Author Ardehali, Hossein
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2004
Subjects
Animals
Apoptosis
Heart - physiology
Humans
Ischemic Preconditioning
Membrane Proteins - physiology
Models, Biological
Myocardium - metabolism
Potassium Channels
Rabbits
Reactive Oxygen Species
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Summary:The mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoK(ATP). These and other studies have also suggested that mitoK(ATP) plays a key role in the process of ischemic preconditioning (IPC) and prevention of apoptosis. The mechanism by which mitoK(ATP) exerts its protective effects is unclear, however, changes in mitochondrial Ca(2+) uptake and levels of reactive oxygen species, and mitochondrial matrix swelling are believed to be involved. Despite major advances, several important issues regarding mitoK(ATP) remain unanswered. These questions include, but are not limited to: the molecular structure of mitoK(ATP), the downstream and upstream mechanisms that leads to IPC and cell death, and the pharmacological profile of the channel. This review attempts to provide an up-to-date overview of the role of mitoK(ATP) in cardioprotection.
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ISSN:0001-527X
1734-154X
DOI:10.18388/abp.2004_3577