Tissue expression of glutathione S transferase isoenzymes in vitiligo

The association of glutathione S-transferase (GST) enzymes with vitiligo is inconclusive. To evaluate tissue expressions of GST isoenzymes in vitiligo patients and to compare these expressions with healthy controls, we used 26 active depigmented patches on the trunk of vitiligo patients and 20 healt...

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Published inBiotechnic & histochemistry Vol. 97; no. 5; pp. 317 - 321
Main Authors Uzuncakmak, Tugba Kevser, Ozkanli, Seyma, Kocdogan, Arzu Kaya, Oguztuzun, Serpil, Karadag, Ayse Serap, Ozlu, Emin, Akdeniz, Necmettin
Format Journal Article
LanguageEnglish
Published Taylor & Francis 04.07.2022
Subjects
Antioxidants
dermatology
glutathione S transferase
human
oxidative stress
pathology
vitiligo
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Summary:The association of glutathione S-transferase (GST) enzymes with vitiligo is inconclusive. To evaluate tissue expressions of GST isoenzymes in vitiligo patients and to compare these expressions with healthy controls, we used 26 active depigmented patches on the trunk of vitiligo patients and 20 healthy sex and age matched controls. Punch biopsies were taken from the lesioned or normal skin. Tissue expression of GST isoenzymes were analyzed immunohistochemically. Tissue expression of GSTT1, GSTA1 and GSTP1 was significantly higher in the patient group than controls. Tissue expression of GSTM1 was not significantly different between the two groups. The increased tissue expression of GSTT1, GSTA1 and GSTP1 may represent a response to excess free radical formation in vitiligo and may support the role of oxidative stress in the pathogenesis of vitiligo.
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ISSN:1052-0295
1473-7760
DOI:10.1080/10520295.2021.1977998