Emerging NIR-II Luminescent Gold Nanoclusters for In Vivo Bioimaging

Gold nanoclusters (AuNCs) with near-infrared II (NIR-II) photoluminescence (PL) have emerged as novel bioimaging probes for in vivo disease diagnosis. So far, it still lacks a systematic review focusing on the synthesis, PL tuning, and in vivo imaging of NIR-II luminescent AuNCs. In this review, we...

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Bibliographic Details
Published inJournal of analysis and testing Vol. 7; no. 3; pp. 260 - 271
Main Authors Ni, Siqi, Liu, Yizhuo, Tong, Shufen, Li, Shihua, Song, Xiaorong
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.09.2023
Subjects
Analytical Chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Monitoring/Environmental Analysis
Review
Bioimaging
NIR-II
Gold nanoclusters
Fluorescent probe
In vivo imaging
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Summary:Gold nanoclusters (AuNCs) with near-infrared II (NIR-II) photoluminescence (PL) have emerged as novel bioimaging probes for in vivo disease diagnosis. So far, it still lacks a systematic review focusing on the synthesis, PL tuning, and in vivo imaging of NIR-II luminescent AuNCs. In this review, we briefly introduce the synthesis of NIR-II luminescent AuNCs using various surface ligands. We discuss the origins and properties of NIR-II PL in AuNCs, and summarize the strategies for improving and/or tuning NIR-II PL emissions. We also provide an overview of the recent progress in the application of AuNCs in tumor-targeted imaging, molecular imaging, and other areas (such as the sensitive imaging of bones, vessels, lymph nodes, etc.). Finally, we present the prospects and challenges in the field of NIR-II luminescent AuNCs and related imaging applications, expecting to offer comprehensive understanding of this field, and thereby deepening and broadening the biological application of AuNCs.
ISSN:2096-241X
2509-4696
DOI:10.1007/s41664-023-00256-0