Fat Fraction Measurements Using a Three-Material Decomposition Dual-Energy CT Technique Accounting for Bone Minerals: Evaluation in a Bone Marrow Phantom Using MRI as Reference

Conventional two-material dual-energy CT (DECT) decomposition is insufficient to model bone marrow, which contains three materials: bone minerals, red marrow (water), and yellow marrow (fat). We explore an image-domain three-material decomposition DECT technique accounting for bone minerals in a bon...

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Bibliographic Details
Published inAmerican journal of roentgenology (1976) Vol. 218; no. 3; pp. 553 - 554
Main Authors Li, Baojun, Hua, Ning, Li, Janelle, Andreu-Arasa, V Carlota, LeBedis, Christina, Anderson, Stephan W
Format Journal Article
LanguageEnglish
Published United States 01.03.2022
Subjects
Bone Marrow - anatomy & histology
Bone Marrow - chemistry
Bone Marrow - diagnostic imaging
Humans
Magnetic Resonance Imaging
Minerals - analysis
Minerals - chemistry
Phantoms, Imaging
Radiography, Dual-Energy Scanned Projection - methods
Tomography, X-Ray Computed - methods
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Summary:Conventional two-material dual-energy CT (DECT) decomposition is insufficient to model bone marrow, which contains three materials: bone minerals, red marrow (water), and yellow marrow (fat). We explore an image-domain three-material decomposition DECT technique accounting for bone minerals in a bone-water-fat phantom. Three-material decomposition fat fraction (FF ) exhibited stronger correlation than two-material decomposition fat fraction (FF ) with MRI-based fat fraction ( = 0.95 vs = 0.69). With increasing bone minerals, correlation of FF remained stable ( = 0.81-1.02), whereas correlation of FF decreased ( = 0.21-0.65).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0361-803X
1546-3141
DOI:10.2214/AJR.21.26407