Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities
In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first st...
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| Published in | Pharmaceutical chemistry journal Vol. 57; no. 9; pp. 1439 - 1443 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.12.2023
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| Abstract | In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first step was reacted with 2-bromoacetophenone derivative compounds and thiazole derivative compounds were obtained. The structures of the synthesized compounds were confirmed by
13
C NMR,
1
H NMR and HRMS spectral findings, and the melting point was determined for these compounds. The % inhibition values of the compounds on the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuCHe) were investigated. |
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| AbstractList | In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first step was reacted with 2-bromoacetophenone derivative compounds and thiazole derivative compounds were obtained. The structures of the synthesized compounds were confirmed by
13
C NMR,
1
H NMR and HRMS spectral findings, and the melting point was determined for these compounds. The % inhibition values of the compounds on the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuCHe) were investigated. |
| Author | Özkay, Yusuf Karakaya, Abdüllatif Erçetin, Tuğba Kaplancıklı, Zafer Asım Çevik, Ulviye Acar |
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| References | SeverBTürkeşCAltıntopMDInt. J. Biol. Macromol.2020163197019881:CAS:528:DC%2BB3cXitVOqsr7K3293183410.1016/j.ijbiomac.2020.09.043 TripathiRKSasiVGuptaSKJ. Enzyme Inhib. Med. Chem.201833137571:CAS:528:DC%2BC2sXhslKls7zJ2909890210.1080/14756366.2017.1389920 XuYJianMMHanCBioorg. Med. Chem. Lett.20203061:CAS:528:DC%2BB3cXitVGqs70%3D3200890610.1016/j.bmcl.2020.126985 ErdoganMKilicBSagkanRIEur. J. Med. Chem.20212121:CAS:528:DC%2BB3MXks1ynsQ%3D%3D3339562310.1016/j.ejmech.2020.113124 TuğrakMGülHİGülçinİJ. Res. Pharm.2020244464471 RajeshwariRChandKCandeiasEMolecules201924358730736397638508710.3390/molecules24030587 SunZQTuLXZhuoFJBioorg. Med. Chem. Lett.20162637477501:CAS:528:DC%2BC28XnsF2gtQ%3D%3D2678318110.1016/j.bmcl.2016.01.001 TaslimiPTürkanFCetinABioorg. Chem.2019921:CAS:528:DC%2BC1MXhs1ygs7fL3147020010.1016/j.bioorg.2019.103213 HemaidaAYHassanGSMaaroufARACS Omega202162919202192111:CAS:528:DC%2BB3MXhs1WmurvM34337258832010710.1021/acsomega.1c02549 GhotbiGMahdaviMNajafiZBioorg. Chem.20201031:CAS:528:DC%2BB3cXhslynsLbJ3289099310.1016/j.bioorg.2020.104186 EllmanGLCourtneyKDAndresVBio. Chem. Pharmacol.1961788951:CAS:528:DyaF3MXht1Gns7o%3D10.1016/0006-2952(61)90145-9 IslamMMRohmanMAGurungABSpectrochim. Acta. A. Mol. BiomolSpectrosc.20181892502571:CAS:528:DC%2BC2sXhtlOhtLnL TemelHEAltintopMDÖzdemirATurkishJ. Pharm. Sci.20181533333381:CAS:528:DC%2BC1MXisVCgsr7O BudakYKocyigitUMGürdereMBSynth. Commun.20174724231323231:CAS:528:DC%2BC2sXhvFWmsLvO10.1080/00397911.2017.1373406 M Erdogan (3007_CR2) 2021; 212 MM Islam (3007_CR9) 2018; 189 RK Tripathi (3007_CR5) 2018; 33 GL Ellman (3007_CR14) 1961; 7 B Sever (3007_CR6) 2020; 163 P Taslimi (3007_CR4) 2019; 92 G Ghotbi (3007_CR3) 2020; 103 HE Temel (3007_CR11) 2018; 15 Y Xu (3007_CR10) 2020; 30 ZQ Sun (3007_CR13) 2016; 26 AY Hemaida (3007_CR1) 2021; 6 Y Budak (3007_CR12) 2017; 47 R Rajeshwari (3007_CR8) 2019; 24 M Tuğrak (3007_CR7) 2020; 24 |
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| Title | Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities |
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