Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities

In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first st...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 57; no. 9; pp. 1439 - 1443
Main Authors Karakaya, Abdüllatif, Çevik, Ulviye Acar, Erçetin, Tuğba, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2023
Subjects
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
acetylcholinesterase
spectroscopic method
butyrylcholinesterase
imidazole
thiazole
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Summary:In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first step was reacted with 2-bromoacetophenone derivative compounds and thiazole derivative compounds were obtained. The structures of the synthesized compounds were confirmed by 13 C NMR, 1 H NMR and HRMS spectral findings, and the melting point was determined for these compounds. The % inhibition values of the compounds on the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuCHe) were investigated.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-03007-8