Delayed-Onset Muscle Soreness: Temporal Assessment With Quantitative MRI and Shear-Wave Ultrasound Elastography

• Published in: American journal of roentgenology (1976) Vol. 208; no. 2; pp. 402 - 412
• Main Authors: Agten, Christoph A., Buck, Florian M., Dyer, Linda, Flück, Martin, Pfirrmann, Christian W. A., Rosskopf, Andrea B.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2017
• Subjects: Adult; Elastic Modulus; Elasticity Imaging Techniques - methods; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - pathology; Muscle, Skeletal - physiopathology; Myalgia - diagnostic imaging; Myalgia - pathology; Myalgia - physiopathology; Reproducibility of Results; Sensitivity and Specificity; Shear Strength; Stress, Mechanical; Young Adult; shear-wave velocity; muscle soreness; MRI; ultrasound elastography
• ISSN: 0361-803X; 1546-3141; 1546-3141
• DOI: 10.2214/AJR.16.16617

The objective of our study was to assess delayed-onset muscle soreness (DOMS) over time using quantitative MRI and shear-wave ultrasound (US) elastography. Five male (mean age ± SD, 39.6 ± 4.6 years) and five female (30.6 ± 13.5 years) volunteers underwent 1.5-T MRI before and after (15 minutes, 1 day, 3 days, 7 days) performing unilateral eccentric resistance exercise of the elbow flexor muscles. The MRI examinations included fluid-sensitive, DWI, and diffusion-tensor imaging sequences of the distal upper arm. Muscle edema, apparent diffusion coefficient (ADC), and fractional anisotropy (FA) were assessed. US of the brachialis muscle was performed before and after (15 minutes, 12 hours, 1 day, 2 days, 3 days, 7 days) exercise to measure mean shear-wave velocity (SWV). Pain and muscle tightness were assessed. For men, muscle edema was moderate and peaked 3 days after exercise; for women, muscle edema was mild and peaked 1-3 days after exercise. ADC was highest 3 days after exercise in men (mean, 1809.22 × 10 mm /s; before exercise, 1529.88 × 10 mm /s) and women (1741.90 × 10 mm /s; before exercise, 1475.80 × 10 mm /s). FA dropped from 361.00 in men and 389.00 in women before exercise to a minimum of 252.12 and 321.28, respectively, 3 days after exercise. Mean SWV increased after exercise in men (before exercise, 3.00 ± 0.30 m/s; peak [15 minutes after exercise], 4.04 ± 0.90 m/s) and women (before, 2.82 ± 0.40 m/s; peak [1 day after exercise], 3.23 ± 0.40 m/s) and subsequently returned to normal. In men, the ADC values of the brachialis muscle positively correlated with mean SWV (r = 0.92, p = 0.028). FA negatively correlated with pain in men (r = -0.993, p = 0.001) Muscle edema outlasted clinical symptoms in most volunteers. FA inversely correlates with pain and may be a useful imaging parameter for assessment of DOMS. Shear-wave US elastography shows a temporary increase of muscle stiffness after DOMS-inducing exercise but does not correlate with quantitative MRI parameters or clinical symptoms.