Antimicrobial Potential of Chitosan Film Incorporated with Microwave-Synthesised Sodium-Doped Carbon Quantum Dots Against Escherichia coli and Staphylococcus aureus

Chitosan films, versatile and valuable in biomedicine, have attracted keen research interest. These films have been subject to modification and crosslinking with various materials to enhance their properties. This study focuses on the crosslinking of microwave-synthesised blue fluorescence sodium-do...

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Bibliographic Details
Published inChemistry Africa Vol. 7; no. 6; pp. 3281 - 3291
Main Authors Zulkfly, Amir Firdaus, Iqbal, Anwar, Ida, Junichi, Mydin, Rabiatul Basria S. M. N., Noh, Nur Asshifa Md, Hussin, M. Hazwan, Al-Fatesh, Ahmed S., Ibrahim, Ahmed A.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.08.2024
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organometallic Chemistry
Original Article
Antimicrobial
Fluorescence
Microwave
Chitosan
Carbon quantum dots
Sodium-doped carbon quantum dots
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Summary:Chitosan films, versatile and valuable in biomedicine, have attracted keen research interest. These films have been subject to modification and crosslinking with various materials to enhance their properties. This study focuses on the crosslinking of microwave-synthesised blue fluorescence sodium-doped carbon quantum dots (Na-CQDs) with chitosan to form a composite film (CHT/Na-CQDs) using the solvent casting method as potential wound dressings. High-resolution transmission electron microscopy and fluorescence spectroscopy were used to determine the particle size of the Na-CQDs (1.0 to 4.5 nm) and quantum yield (12.3%). X-ray diffraction indicates that Na-CQDs have an amorphous structure resembling the hexagonal phase of graphite. The proposed crosslinking mechanism between chitosan and Na-CQDs involves chemical bonding, hydrogen bonding, and electrostatic attraction. The CHT/Na-CQDs has lower crystallinity compared to Na-CQDs. The swelling capacity of CHT/Na-CQDs (715%) was significantly lower than that of the chitosan film (2300%). Antibacterial testing demonstrated a higher potential of CHT/Na-CQDs against Staphylococcus aureus , a Gram-positive bacterium, compared to Escherichia coli , a Gram-negative bacterium.
ISSN:2522-5758
2522-5766
DOI:10.1007/s42250-024-01026-w