The effects of gamma-aminobutyric acid on prolactin and gonadotropin secretion in the unanesthetized rat

The effects of the intraventricular injection of gamma-aminobutyric acid (GABA) on pituitary secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin (PRL) were examined in Na-pentobarbital (PB)-anesthetized and unanesthetized male rats. GABA (5 or 10 millimicronmol)...

Full description

Saved in:
Bibliographic Details
Published inEndocrinology (Philadelphia) Vol. 100; no. 5; p. 1437
Main Authors Pass, K A, Ondo, J G
Format Journal Article
LanguageEnglish
Published United States 01.05.1977
Subjects
Aminobutyrates - pharmacology
Animals
Follicle Stimulating Hormone - blood
gamma-Aminobutyric Acid - pharmacology
Luteinizing Hormone - blood
Male
Pentobarbital - pharmacology
Prolactin - blood
Rats
Online AccessGet more information

Cover

More Information
Summary:The effects of the intraventricular injection of gamma-aminobutyric acid (GABA) on pituitary secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin (PRL) were examined in Na-pentobarbital (PB)-anesthetized and unanesthetized male rats. GABA (5 or 10 millimicronmol) injected into the lateral ventricle of PB anesthetized rats resulted in significant elevations in plasma concentrations of LH and PRL. When administered via a lateral ventricle cannula to unanesthetized rats, GABA (1, 5, or 10 millimicronmol) caused a significant increase in plasma PRL levels but had no effect on plasm LH concentrations. Plasma FSH was uninfluenced by GABA in all animals studied. The data indicate that PB anesthesia can alter the hypothalamic pituitary axis to a possible neurotransmitter agent.
ISSN:0013-7227
DOI:10.1210/endo-100-5-1437